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Information about Phenergan

Promethazine is a phenothiazine antihistamine that is used for relieving allergy symptoms, including hives and nasal congestion. As an antihistamine it blocks the sights where histamine acts. Also it may be used to prevent and control pain and nausea during and after surgery. Moreover, it helps to produce light sleep and prevents motion sickness. Promethazine is not used for treatment of asthma. Promethazine may also be administered to treat other conditions as determined by your physician.

You should not use Promethazine in case you have any condition mentioned below: you are allergic to any ingredient in Promethazine; you have a severe central nervous system depression or are in a coma; you are also taking astemizole, cisapride, terfenadine, or tramadol.

In such cases it is obligatory to consult with your doctor or health care provider before taking this medicine.

Before using Promethazine

Before using Promethazine you should tell your doctor if you have any medical conditions listed below: you are pregnant, plan to become pregnant, or are breast-feeding a baby; you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement; if you have allergies to medicines or other substances; you have nervous system problems, bone marrow depression, heart problems, a blood disease, glaucoma, increased eye pressure, low blood pressure, liver problems, prostate problems, Parkinson disease, seizures, or Reye syndrome; you regularly consume large amounts of alcohol.

Be aware that Promethazine may interact with some medicines. Consult with your health care provider in case you are taking any other drugs, especially any of the next: charcoal or lithium because the effectiveness of Promethazine may be decreased; angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), astemizole, cisapride, general anesthetics (eg, thiopental), methyldopa, terfenadine, or tramadol because the risk of side effects such as low blood pressure and seizures may be increased; ACE inhibitors (eg, enalapril), haloperidol, lithium, meperidine, metrizamide, monoamine oxidase (MAO) inhibitors (eg, phenelzine), naltrexone, polypeptide antibiotics (eg, actinomycin), or trazodone because the actions and the risk of side effects of these medicines may be increased; bromocriptine, epinephrine, levodopa, or pergolide because the effectiveness of these drugs may be decreased by Promethazine.

It may not be a complete list of all interactions with other drugs. To prevent any complications you should check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Promethazine

You should use Promethazine as recommended by your doctor. Take it with or without food. In case stomach upset takes place, you should take Promethazine with food to prevent irritation of the stomach.

To prevent motion sickness, it is better to take a dose at least 30 to 60 minutes before traveling.

In case you miss a dose, take it as soon as possible. If it is almost time for your next intake, skip the missed dose and take it according to your regular dosing schedule. Do not take double doses at once.

Important safety information

Famotidine usage may lead to dizziness and drowsiness. These effects may be worsening by taking alcohol or certain medicines (eg, sedatives, tranquilizers). You should know that Promethazine elevates the effects of alcohol and depressants. Prevent driving or performing any other possibly unsafe actions.

Neuroleptic malignant syndrome (NMS) is a potentially deadly syndrome. It is associated with Promethazine usage. Symptoms of this syndrome are increased body heat; muscle rigidness; altered mental abilities, including lack of response to your surroundings; irregular pulse and blood pressure; increased heart rate; sweating; irregular heart rhythm. Consult with your doctor immediately if you have any of symptoms mentioned above.

Your eyes may be more sensitive to sunlight while taking Promethazine. Try to avoid exposure to the sun, sun lamps, or tanning booths. You should use a sunscreen or protective clothing in case you are not able to prevent such exposure.

The elderly are likely to be more sensitive to the effects of this drug. Use Promethazine with extreme caution in this group.

Do not use Promethazine in CHILDREN under 2 years of age because serious, and sometimes fatal, side effects (difficult or slowed breathing, drowsiness leading to coma) may occur. Use Promethazine with extreme caution in children 2 years of age and older.

PREGNANCY and BREAST-FEEDING

In case you are pregnant or plan pregnancy consult with your doctor and discuss the benefits and risks of taking Promethazine during pregnancy. It is known that Promethazine passes into breast milk. In case you are or you will be breast-feeding a baby, consult with your doctor or pharmacist.

Possible side effects of Promethazine

You should consult with your doctor in case you have any of side effects especially bothersome listed below: dizziness; drowsiness; dry mouth; increased or decreased blood pressure; nausea; occasional blurred vision; rash; sleepiness; vomiting.

Seek emergency in case you have any of these severe side effects: severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); sensitivity to light; uncontrolled muscle movements; yellowing of skin or eyes.

What is the expiration date of the pills?

This information is mentioned on each blister. The expiration date is 2 years from the date of manufacture.