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Information about Isosorbide

Isosorbide Dinitrate is a nitrate vasodilator that is used for preventing angina (chest pain) that may be caused by heart disease. It widens the blood vessels in the body and decreases the workload of the heart. It helps to relieve chest pain.

You should not use Isosorbide Dinitrate in case you have any condition mentioned below: you are allergic to any ingredient in Isosorbide Dinitrate; you are taking a phosphodiesterase type 5 inhibitor (eg, sildenafil), a medicine often used for sexual dysfunction.

In such cases it is obligatory to consult with your doctor or health care provider before taking this drug.

Before using Isosorbide Dinitrate

Before using Isosorbide Dinitrate you should tell your doctor if you have any medical conditions listed below: you are pregnant, planning to become pregnant, or are breast-feeding a baby; you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement; you have allergies to medicines, foods, or other substances; you have bleeding in the brain, a recent head trauma, an overactive thyroid, heart problems (eg, heart failure, cardiomyopathy, history of heart attack), or anemia (a low red blood cell count).

Be aware that Isosorbide Dinitrate may interact with some medicines. Consult with your health care provider in case you are taking any other drugs, especially any of the following: ethanol or phosphodiesterase type 5 inhibitors (eg, sildenafil) because side effects, such as extremely low blood pressure, dizziness, or fainting, may occur.

It may not be a complete list of all interactions with other drugs. To prevent any complications you should check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Isosorbide Dinitrate

Take this medicine as prescribed by your physician. It is recommended to place Isosorbide Dinitrate under the tongue and dissolve it. Avoid breaking, crushing, or chewing this drug unless your doctor recommends otherwise.

In case you miss a dose of Isosorbide Dinitrate, take it as soon as possible. If it is almost time for your next intake, skip the missed dose and take it according to your regular dosing schedule. Do not take double doses to catch up.

Important safety information

Isosorbide Dinitrate usage may lead to dizziness or drowsiness. These effects may be worsened by taking alcohol or certain medicines. Prevent driving or performing any other possibly dangerous actions.

Be aware that alcohol, hot weather, exercise, or fever may increase dizziness or lightheadedness while taking Isosorbide Dinitrate. For the purpose of dizziness or lightheadedness prevention, try to sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

You may experience headaches when you begin taking Isosorbide Dinitrate. It is normal reaction. You should not change your dosing schedule to avoid headaches but take aspirin or acetaminophen.

Do not use Isosorbide Dinitrate in CHILDREN as safety and effectiveness in children have not been confirmed.

PREGNANCY and BREAST-FEEDING

In case you become pregnant, consult with your doctor and discuss the benefits and risks of taking Isosorbide Dinitrate while pregnancy. It is not clear whether Isosorbide Dinitrate passes into breast milk. In case you are or will be breast-feeding a baby while you take Isosorbide Dinitrate, consult with your doctor and discuss any possible risks to your baby.

Isosorbide Dinitrate may not work properly in case it is used for long periods of time without a break. It is TOLERANCE. You should know that it is not effective to increase the dose in such situation. It is important to have a "nitrate-free" period of time each day to prevent the tolerance. Consult with your doctor in case Isosorbide Dinitrate stops working well.

The other condition you may experience in case you take Isosorbide Dinitrate for a long time without a break is DEPENDENCE. In this situation you may have WITHDRAWAL symptoms. They include chest pain, heart attack, or possibly sudden death. It is important to have a "nitrate-free" period of time each day to prevent dependence and withdrawal problems.

Possible side effects of Isosorbide Dinitrate

You should consult with your doctor in case you have any of side effects especially bothersome listed below: dizziness; flushing of the face and neck; headache; lightheadedness.

Seek emergency immediately in case you have any of these severe side effects: severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fainting; frequent, continuing, or severe chest pain; nausea; rapid or slow heartbeat; vomiting.

What is the expiration date of the pills?

This information is mentioned on each blister. The expiration date is 2 years from the date of manufacture.